生物信息學實驗室
| Location | E11-1048 |
| Academic Staff in charge | Prof. Shirley W. I. SIU |
| Technician | Hok Lam SIO, William; Francisco DE OLIVEIRA |
| Telephone | (853) 8822-4285, 4295 |
| Open Access Reservation Period | Wednesday: 9:00 - 17:00 |
| Laboratory Website | http://cbbio.cis.umac.mo/ |
Objective
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Facilities |
Courses supported |
Related Links
Objective
In the Computational Biology and Bioinformatics Laboratory, our focus is on the development and application of bioinformatics tools to solve complex biological problems. In particular, we are interested in studying molecular recognition processes between protein-protein, protein-ligand, and protein-solid surface. The former two are important for understanding protein function as well as for rational drug design studies, while the latter is crucial for the engineering of nanomaterial and nano-devices.
Our current projects include
- Structure prediction of transmembrane protein complexes from amino acid sequences
- Docking pose prediction of small ligands in proteins
- Optimization of the virtual screening pipeline for rational drug discovery
- Orientation prediction of proteins on solid surfaces
- Development of molecular force fields
Facilities
Computer
- HP Proliant BL460c Generation 8 (G8) 1x 24 cores cluster node with 64 GB RAM
- Dell Precision T7610 workstation 2x Intel Xeon E5-2620 v2 six-core with 16 GB RAM
- Intel Core i7 quad-core desktop computers such as HP Compaq 8300 and Dell XPS 8700
- 13-inch MacBook Pro with 2.8GHz Dual-core Intel Core i7, 8 GB RAM
Software
- IDL (Interactive Data Language) for data visualization
- GROMACS for molecular dynamics simulations
Courses supported
| CISB366 | Bioinformatics |
| CISB410 | Final Year Project |
Related Links
Homepage of P.I. http://www.cis.umac.mo/~shirleysiu