Seminar on Mathematical Model for Cold Syndrome
Speaker:Prof. WANG Miqu
Chengdu University of Traditional Chinese Medicine
Date & Time:17 Dec 2007 (Monday) 16:00 - 16:55
Venue:JM07

Abstract

We have done much work about cold syndrome-gene expression profile, but there is an urgent need for the information fusion. Based on 6 times NSFCs for 10 years, we conclude that the cold syndrome is mainly involved in the disorder of energy metabolism. Since we are puzzled at informational mining of great data, new mathematical methods to establish the math model of cold syndrome is of central importance. On the basis of previous research on cold syndrome-genome at Chengdu, we analyzed the data of 400 thousands of symptom, 3.3 millions of gene expression, 2.2 millions of single nucleotide polymorphism of cold syndrome. Through Means Cluster, Support Vector Machines, Gene Set Enrichment Analysis, especially the newly developed mathematical methods we are now carrying on the correlative research between cold syndrome and gene expression profile to establish the primary math model of cold syndrome-genome.

通過六次國家自然基金資助的十年研究,雖逐步集中於寒證證候與能量代謝基因模組異動的生物學意義,但是存在著海量資料資訊挖掘的困惑和數學方法的匱乏,迫切需要數學方法,解決關健性的計算問題,創建數學模型。該項研究基於成都寒證證候基因組研究平臺資源的基礎上,將積累了的40萬寒證症狀的宏觀資料,330萬寒證基因表達譜資料,220多萬條的單核苷酸多態等實驗的微觀資料,進行資訊挖掘。擬通過平滑聚類、支持向量機、基因功能富集分析等數學方法的處理,探求新的數學方法以實現對虛寒證及其證候與基因表達譜的相關性的研究,初步建立寒證證候-基因組的數學模型雛型。