Quantitative Emission Computed Tomography
Speaker:Dr. Yong Du
Johns Hopkins University, USA
Date & Time:25 Jul 2011 (Monday) 11:00
Organized by:Department of Electrical and Computer Engineering


Emission computed tomography (ECT), including single photon emission computed tomography (SPECT) and positron emission tomography (PET), is a noninvasive 3D tomographic method that is widely used in both clinical diagnosis and academic research of many diseases. In ECT imaging, the 3D distribution of a radio-labeled pharmaceutical administrated to a patient is measured by detecting the gamma-photons emitted by the attached radioactive isotope. Because ECT agents can be designed to target specific physiological and biochemical functions, ECT images can provide information about both physiologic and physiopathologic processes inside the human body at the molecular level. Especially, quantitative estimates of regional activities from ECT images can provide additional information in the evaluation of various physiological functions, such as myocardial perfusion, neurotransmission, and tumor metabolic status, etc. Kinetic modeling of tracer uptake from dynamic images based on regional activity estimates allows further quantifying of these functions in absolute terms. Thus, quantitative ECT imaging has become a unique tool for in vivo assessment of physiological function and an important diagnostic and prognostic tool for many diseases. However, the quantitative accuracy of ECT images is degraded by many factors inherent in the imaging physics, such as attenuation, scatter, random coincidences, and partial volume effects (PVEs). We have been intensively studied those imaging degrading factors and developed robust compensation methods. When combined with statistical iterative reconstruction algorithm, the accuracy of quantitative ECT images can be significantly improved. In this talk, a summary of our work will be presented and several clinical applications will be demonstrated.


Dr. Yong Du graduated in Biophysics from Nankai University. He received his M.S. in Biophysics in 1998 from Nankai University, and Applied Physics in 2000 from East Caroline University, respectively. In 2004, he received his Ph.D. in Biomedical Engineering from University of North Carolina at Chapel Hill. From 2004 to 2009 he was a Postdoctoral Fellow and then a Research Associate in the Department of Radiology at the Johns Hopkins University. In 2010 he became an Instructor at the Johns Hopkins University. He has served as Assistant Chair for the IEEE Medical Imaging Conference in 2007; Associate Guest Editor for international journal Medical Physics; and the author of over 20 international journal papers.