3D Bioprinting has opened a new avenue for tissue engineering and regenerative medicine, with the ability to directly manipulate living cells. Despite the considerable progress in the last decade, 3D bioprinting has long been subjected to trade-offs between physicochemical and biological outcomes. The resulting material properties of the initial bioinks, which are typically cell-laden formulations, and final printing products usually lie within a moderate range, which limits the application of bioprinting and its products. Recent progress in bioinks and bioprinting techniques has significantly expanded the window of material properties. In this talk, I will define two bioprinting windows to clarify the trade-offs between physical chemistry and biology. I will illustrate it with examples from our team and others that have pushed the rheological boundaries of bioinks and mechanical boundaries of bioprints, focusing on unusual material properties.
Dr. Ouyang is currently an Assistant Professor in the Department of Mechanical Engineering at Tsinghua University. He obtained a Ph.D. degree in Materials Science and Engineering at Tsinghua University (2017), postdoctoral training in Materials and Bioengineering at Imperial College London (2017-2020), and a visiting research training in Bioengineering at the University of Pennsylvania (2015-2016). His research interests include the design, fabrication, and application of complex biomaterial and cellular systems, with a central focus on the development of 3D bioprinting and advanced biofabrication technologies for engineering in vitro living systems. He has published a series of peer-reviewed articles in well-recognized journals, including Science Advances, Advanced Materials, Materials Today, and Trends in Biotechnology, with a total citation of 2500+ and an H-index of 16. He is currently an Associate Editor of the International Journal of Bioprinting, Youth Editorial Board Member of BMEMat, Guest Editor of Biomaterials Advances, and Early Career Researcher Committee Member of ISBF. He has been recognized with a series of awards, including the ISBF New Investigator Award (2021), IOP Top Cited Author Award (2018), Distinguished Doctorate of Tsinghua University (2017), and GE Foundation TECH Award First Place (2016).